The role of cytokines in the pathogenesis of malignant neoplasms

The paper analyzes the literature data on role of cytokines in pathogenesis malignant neoplasms (MN). Cytokines are biologically active, hormone-like proteins that regulate a wide range processes occurring body. determine type and duration immune response, stimulation or suppression cell growth, their differentiation, functional activity. complex produced tumor microenvironment plays an important MN. spectra biological activities overlap most cases. same process can be stimulated by more than one cytokine, creating favorable environment for initiation progression system recognize transformed cells. Various correspond to specifc pathways activated receptors surface, which turn cause intracellular signaling cascades affect target cellular functions. Cytokine genes mutually related oncogenes. Cytokines, released response infection, inflammation, during antigen, inhibit development. In turn, cytokines, weaken apoptosis promote invasion metastasis, growth. involved initiation, development metastasis through various mechanisms.